Throw some really awful and large creatures at your opponents' faces.
Mostly, you want Brion in play to fling stuff at people. Sometimes, you can steal their good stuff and fling it as psuedo-removal. Pretty straightforward. The face is the place.
You can semi-oneshot people with an activated Evra, a big Phyrexian Processor token, or Serra Avatar.
Grafted Exoskeleton makes Brion very very scary.
This is a pretty straightforward deck that relies on the commander to do much of anything. You'll be sad if the table kills Brion a bunch.